[The regional characteristics of endocrine pathology in the Perm kraii].

Nowadays, focus of research is shifted to epidemiology of non-communicable diseases. Hence, actuality of study purpose to investigate epidemiological characteristics of endocrine diseases. The data of population appealability to medical organizations in the Perm region during last 20 years was used. The levels and structure of morbidity were calculated. The dynamic process was evaluated. The trend prognostication was proposed. In 2017, total endocrine system morbidity in the Perm region made up to 88.1 cases per 1000 population. During last 20 years, primary and total morbidity has tripled. In 2006, 2013 and 2015 maximal levels of primary morbidity are conditioned by adoption of a number of legal acts targeted to detection of pathology. The pathology of diseases of the endocrine system is determined by diabetes mellitus, thyroid diseases and obesity in 87.1% of all cases. According the data of population appealability to medical organizations, the rate of prevalence of obesity in 2017 made up to 10.6, diabetes mellitus - 26.6, thyroid diseases - 23.4 per 1000 of population. During last 20 years, incidence of diabetes mellitus increased up to 2 times, and obesity up to 4.8 times. The females suffered of obesity 1.2 times and of thyroid diseases 7.4 times more often than males.

[The epidemiologic characteristic of diabetes mellitus and its complications].

The article presents dynamics of prevalence, mortality and disability due to diabetes mellitus at the territory of Perm kraiy during last 10 years. The rate of diseases' complications and mean life interval are also considered. The materials of analysis made it possible to evaluate the epidemiological situation in kraiy and to develop activities to change it.

[Clinical, metabolic and hormonal changes in patients with obesity on low-calorie diet therapy]. / Klinicheskie, metabolicheskie, gormonal'nye izmeneniia u bol'nykh ozhireniem pri provedenii razgruzochno-dieticheskoi terapii.

Low-calorie diet therapy (LCDT) was used to treat obesity in 74 females aged 18-49 in four regimens: short-term (up to 7 days), of middle duration (10-14 days), long-term (up to 21-24 days) and fractionated. Middle duration of LCDT proved most favourable. Long-term fasting may bring unstable effects or complications. LCDT results in electrolyte unbalance, hypokalemia, hypokaligestia. Relevant correction is necessary on the diet day 5-6. Red cell count, blood levels of sugar and protein, lipidogram, nitrogenous metabolism, coagulation activity changed insignificantly. Obese patients on LCDT exhibited reduced hyperinsulinism responsible for body mass decrease, hyperproduction of hydrocortisone and prolactin enhancing fat synthesis. They also developed T3-hypothyrosis reducing thermogenesis. The changes in the body mass depended on these factors.